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feat(skills): add public variant evidence routing - #3
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Summary
Adds a focused
bio-public-variant-evidenceskill and routes eligible publicsingle-variant questions to it from the omics scientist agent.
The workflow uses Folklore Clinical Variant Interpretation MCP, published by
Helena Bioinformatics, for source-linked public variant evidence and
variant-linked literature. It preserves the live resolution outcome, stops on
ambiguity, and chains literature only after a variant is resolved. It also
routes broad annotation, arbitrary database lookup, VCF-wide analysis, and
unsupported variant classes to the repository's existing skills instead of
expanding this skill's scope.
The skill accepts one public GRCh38 germline nuclear SNV or simple indel. It
does not accept patient, phenotype, family, segregation, or private case data.
Results require qualified professional review and are not a diagnosis or
treatment recommendation.
Changes
skills/bio-public-variant-evidence/SKILL.mdwith explicit inputs,outputs, outcome branching, composition rules, and quality gates;
and recognition patterns;
source-linked publications, plus a negative VCF/VEP/ClinVar regression;
Validation
python scripts/validate-skills.py: passedpython scripts/validate-supplementary-docs.py: passedtools/list: returned the four documented toolsrs80357914smoke test:ambiguous, two candidates, no automatic selectionThe full test suite reports 291 passed and 4 failed on macOS. The same four
failures reproduce on the unchanged
maincommit and are caused by existingGNU
realpath -massumptions and macOS/varversus/private/varpathaliasing; none touches this skill or routing change.
Public references
io.github.helena-bioinformatics/folklore