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docs: add SEED-007/005 reviewer notes to EXPERT_REVIEW_PACK, Met oxidation limitation row - #92

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feat/expert-review-seed-notes
Jun 28, 2026
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Summary

Adds parallel reviewer notes for SEED-007 and SEED-005 to EXPERT_REVIEW_PACK.md (Section 5), matching the existing notes for SEED-008 and SEED-009. Adds a Pipeline Limitations row for SEED-007 Met oxidation.

SEED-007 reviewer note

  • Largest family (26 selected, 4 pilot slots at ranks 3/4/5/8), all NOVEL
  • Met at position 6 in all 4 pilot variants — Nle substitution or argon storage required; HPLC purity mandatory at receipt
  • Serum 0.636–0.662: best raw score among NOVEL pilot families
  • SAR framing: compare MIC vs parent Bombolitin-II (IKFTTMLKKLG)

SEED-005 reviewer note

  • Only 1 pilot slot (rank 19, CLOSE_RELATIVE, 60% similarity)
  • Lowest-priority family — defer if synthesis budget must be reduced
  • Lowest safety score (0.845); HC₅₀ mandatory; deprioritise Wave 2 if HC₅₀ < 10× MIC

Pipeline Limitations table

  • New row: "SEED-007 Met oxidation (all 4 pilot variants)" — expert reviewer must be aware

Test plan

  • 1304 tests pass (pre-push hook verified)

🤖 Generated with Claude Code

SEED-007 (bombolitin-II) reviewer note: largest family (26 selected, 4 pilot
slots ranks 3/4/5/8), all NOVEL; Met oxidation warning for all 4 pilot variants;
serum stability 0.636–0.662 best among NOVEL families; VAR_009 primary SAR
comparison vs parent bombolitin-II.

SEED-005 (cecropin-magainin) reviewer note: lowest-priority pilot family (rank 19,
CLOSE_RELATIVE), lowest safety score (0.845); deprioritise if budget-constrained.

Pipeline Limitations table: new row for SEED-007 Met oxidation risk (all 4 pilot
variants; Nle substitution or argon storage required).

DISCOVERY_PREDICTION.md and ROADMAP.md tracking updated through PR #101.
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cschanhniem merged commit 12268e8 into main Jun 28, 2026
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cschanhniem deleted the feat/expert-review-seed-notes branch June 28, 2026 18:19
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