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docs: update ROADMAP, add AUROC reproducibility, update RISK_REVIEW - #56
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ROADMAP.md: - Mark v0.1-v0.5 as complete (✓) with specifics of what was delivered in each milestone - Add v0.5.x section documenting the pre-wet-lab scoring enhancements (PRs #31-#54): serum stability, selectivity proxy, pilot priority, aggregation, proline penalty, helix bonus, amidation/acetylation recommendations, DISCOVERY_PREDICTION model METHODS.md Section 8: - Add 'To reproduce: make validate-scoring' note so reviewers can reproduce AUROC 0.8164 from the repository without external tooling (addresses code review feedback that the headline performance number was not reproducible from visible code) RISK_REVIEW.md Section 2: - Add selectivity proxy / HIGH_CYTOTOX_RISK as a dedicated filtered risk row; both the safety scorer (μH penalty, pH-7.4 charge) and pilot panel (cytotox_penalty) now double-mitigate cytotoxicity risk - Update hydrophobicity row to mention μH > 0.55 signal added in PR #53 - Update charge density row to note charge_density_ph74 for accuracy - Add proline content as a reported risk row - Update action-required note to flag HIGH_CYTOTOX_RISK candidates for hemolysis assay
… PR #56) validate-scoring is a top-level command, not a bench subcommand. 'cli bench validate-scoring' would raise argparse error. Corrected to 'cli validate-scoring' to match the actual Makefile target.
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Summary
make validate-scoringreproducibility instruction so reviewers can reproduce AUROC 0.8164 from the repo — addresses code review finding that headline performance numbers were not reproducible from visible codeTest plan
make ci)ruff checkpasses🤖 Generated with Claude Code