Data, scripts, and figures for the C. briggsae anthelmintic dose response (DRC) micropublication
Parasitic nematodes are treated with anthelmintic drugs; however, anthelmintic resistance (AR) is rising, and underlying causes must be identified. The free-living nematode Caenorhabditis briggsae was used as a tractable model to study AR mechanisms. Six genetically diverse C. briggsae strains were exposed to nine anthelmintic drugs, and dose-response curves were created to quantify effective concentrations, slope estimates, and heritability. Findings reveal significant strain-level variation in anthelmintic responses within and across drug classes, demonstrating the importance of incorporating genetic diversity into AR studies. Heritable drug responses prioritize conditions for genome-wide association studies that discover AR genes.