diff --git a/Tests/test_imageops.py b/Tests/test_imageops.py
index 4a4826d22e3..9557e02fd61 100644
--- a/Tests/test_imageops.py
+++ b/Tests/test_imageops.py
@@ -484,6 +484,56 @@ def check(orientation_im: Image.Image) -> None:
     assert 0x0112 not in transposed_im.getexif()
 
 
+@pytest.mark.parametrize("info_key", ["XML:com.adobe.xmp", "xmp"])
+@pytest.mark.parametrize("in_place", [False, True])
+@pytest.mark.parametrize(
+    "orientation",
+    [
+        'tiff:Orientation="6"',
+        "tiff:Orientation='6'",
+        'tiff:Orientation = "6"',
+        "tiff:Orientation\n=\t'6'",
+        'tiff:Orientation=" 6 "',
+        "<tiff:Orientation>6</tiff:Orientation>",
+        "<tiff:Orientation>\n 6\t</tiff:Orientation>",
+        "<tiff:Orientation >6</tiff:Orientation >",
+    ],
+)
+def test_exif_transpose_xmp_xml_syntax(
+    info_key: str, in_place: bool, orientation: str
+) -> None:
+    im = Image.new("RGB", (2, 1))
+    im.putpixel((0, 0), (255, 0, 0))
+    im.putpixel((1, 0), (0, 0, 255))
+    expected = im.transpose(Image.Transpose.ROTATE_270)
+    namespaces = (
+        'xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" '
+        'xmlns:tiff="http://ns.adobe.com/tiff/1.0/"'
+    )
+    if orientation.startswith("<"):
+        xmp = (
+            f"<rdf:RDF {namespaces}><rdf:Description>"
+            f"{orientation}</rdf:Description></rdf:RDF>"
+        )
+    else:
+        xmp = f"<rdf:RDF {namespaces}><rdf:Description {orientation}/></rdf:RDF>"
+    im.info[info_key] = xmp if info_key == "XML:com.adobe.xmp" else xmp.encode()
+
+    assert im.getexif()[0x0112] == 6
+    if in_place:
+        ImageOps.exif_transpose(im, in_place=True)
+        transposed = im
+    else:
+        transposed = ImageOps.exif_transpose(im)
+        assert im.size == (2, 1)
+        assert im.getexif()[0x0112] == 6
+    assert_image_equal(transposed, expected)
+    assert "tiff:Orientation" not in str(transposed.info[info_key])
+    transposed._reload_exif()
+    assert 0x0112 not in transposed.getexif()
+    assert_image_equal(ImageOps.exif_transpose(transposed), expected)
+
+
 def test_exif_transpose_with_xmp_tuple() -> None:
     with Image.open("Tests/images/xmp_tags_orientation.png") as im:
         assert im.getexif()[0x0112] == 3
diff --git a/docs/releasenotes/13.0.0.rst b/docs/releasenotes/13.0.0.rst
index 5ec4c3d1485..fbb892999b3 100644
--- a/docs/releasenotes/13.0.0.rst
+++ b/docs/releasenotes/13.0.0.rst
@@ -99,6 +99,15 @@ intended for internal use, so there is no replacement.
 API changes
 ===========
 
+XMP orientation whitespace and quotation marks
+^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^
+
+:py:meth:`~PIL.Image.Image.getexif` now reads XMP orientation attributes
+with single quotes or whitespace around the equals sign and orientation value.
+Whitespace around an orientation element's value is also supported.
+:py:func:`~PIL.ImageOps.exif_transpose` removes these forms after transposition,
+so reloading the metadata does not cause the image to be transposed again.
+
 TODO
 ^^^^
 
diff --git a/src/PIL/Image.py b/src/PIL/Image.py
index 4bb7c51aaad..dcaba62b9bc 100644
--- a/src/PIL/Image.py
+++ b/src/PIL/Image.py
@@ -1666,13 +1666,13 @@ def getexif(self) -> Exif:
         # XMP tags
         if ExifTags.Base.Orientation not in self._exif:
             xmp_tags = self.info.get("XML:com.adobe.xmp")
-            pattern: str | bytes = r'tiff:Orientation(="|>)([0-9])'
+            pattern: str | bytes = r"tiff:Orientation\s*(?:=\s*[\"']\s*|>\s*)([0-9])"
             if not xmp_tags and (xmp_tags := self.info.get("xmp")):
-                pattern = rb'tiff:Orientation(="|>)([0-9])'
+                pattern = rb"tiff:Orientation\s*(?:=\s*[\"']\s*|>\s*)([0-9])"
             if xmp_tags:
                 match = re.search(pattern, xmp_tags)
                 if match:
-                    self._exif[ExifTags.Base.Orientation] = int(match[2])
+                    self._exif[ExifTags.Base.Orientation] = int(match[1])
 
         return self._exif
 
diff --git a/src/PIL/ImageOps.py b/src/PIL/ImageOps.py
index 593f801b031..6407e3b579f 100644
--- a/src/PIL/ImageOps.py
+++ b/src/PIL/ImageOps.py
@@ -750,8 +750,8 @@ def exif_transpose(image: Image.Image, *, in_place: bool = False) -> Image.Image
             for key in ("XML:com.adobe.xmp", "xmp"):
                 if key in exif_image.info:
                     for pattern in (
-                        r'tiff:Orientation="([0-9])"',
-                        r"<tiff:Orientation>([0-9])</tiff:Orientation>",
+                        r"tiff:Orientation\s*=\s*([\"'])\s*[0-9]\s*\1",
+                        r"<tiff:Orientation\s*>\s*[0-9]\s*</tiff:Orientation\s*>",
                     ):
                         value = exif_image.info[key]
                         if isinstance(value, str):