diff --git a/packages/mui-material/src/Select/Select.test.js b/packages/mui-material/src/Select/Select.test.js
index 3f00a1fd016584..9279ba200a80c3 100644
--- a/packages/mui-material/src/Select/Select.test.js
+++ b/packages/mui-material/src/Select/Select.test.js
@@ -2220,6 +2220,21 @@ describe('<Select />', () => {
       expect(options[2]).not.to.have.attribute('aria-selected', 'true');
     });
 
+    it('should deselect an option whose value matches the selection by stringified equality', () => {
+      const onChange = spy();
+      render(
+        <Select multiple open value={['10', '20']} onChange={onChange}>
+          <MenuItem value={10}>Ten</MenuItem>
+          <MenuItem value={20}>Twenty</MenuItem>
+        </Select>,
+      );
+
+      fireEvent.click(screen.getAllByRole('option')[0]);
+
+      expect(onChange.callCount).to.equal(1);
+      expect(onChange.firstCall.args[0].target.value).to.deep.equal(['20']);
+    });
+
     it("selects values based on strict equality if they're objects", () => {
       const obj1 = { id: 1 };
       const obj2 = { id: 2 };
@@ -2506,6 +2521,44 @@ describe('<Select />', () => {
     expect(screen.getByRole('combobox')).to.have.text('France');
   });
 
+  it('should handle the browser autofill event for non-string option values', () => {
+    const onChangeHandler = spy();
+    const { container } = render(
+      <Select onChange={onChangeHandler} defaultValue={20} name="age">
+        <MenuItem value={10}>Ten</MenuItem>
+        <MenuItem value={20}>Twenty</MenuItem>
+      </Select>,
+    );
+    fireEvent.change(container.querySelector('input[name="age"]'), {
+      target: {
+        value: '10',
+      },
+    });
+
+    expect(onChangeHandler.callCount).to.equal(1);
+    expect(onChangeHandler.firstCall.args[0].target.value).to.equal(10);
+    expect(screen.getByRole('combobox')).to.have.text('Ten');
+  });
+
+  it('should handle the browser autofill event when multiple', () => {
+    const onChangeHandler = spy();
+    const { container } = render(
+      <Select multiple onChange={onChangeHandler} defaultValue={[]} name="age">
+        <MenuItem value={10}>Ten</MenuItem>
+        <MenuItem value={20}>Twenty</MenuItem>
+      </Select>,
+    );
+    fireEvent.change(container.querySelector('input[name="age"]'), {
+      target: {
+        value: '10',
+      },
+    });
+
+    expect(onChangeHandler.callCount).to.equal(1);
+    expect(onChangeHandler.firstCall.args[0].target.value).to.deep.equal([10]);
+    expect(screen.getByRole('combobox')).to.have.text('Ten');
+  });
+
   // see https://github.com/jsdom/jsdom/issues/123
   it.skipIf(isJsdom())('should support native form validation', function test() {
     const handleSubmit = spy((event) => {
diff --git a/packages/mui-material/src/Select/SelectInput.js b/packages/mui-material/src/Select/SelectInput.js
index 7c2027f0dac1bf..efacffe13fe70c 100644
--- a/packages/mui-material/src/Select/SelectInput.js
+++ b/packages/mui-material/src/Select/SelectInput.js
@@ -461,21 +461,6 @@ const SelectInput = React.forwardRef(function SelectInput(props, ref) {
 
   const childrenArray = React.Children.toArray(children);
 
-  // Support autofill.
-  const handleChange = (event) => {
-    const child = childrenArray.find((childItem) => childItem.props.value === event.target.value);
-
-    if (child === undefined) {
-      return;
-    }
-
-    setValueState(child.props.value);
-
-    if (onChange) {
-      onChange(event, child);
-    }
-  };
-
   const handleValueChange = (event, child, newValue) => {
     setValueState(newValue);
 
@@ -496,6 +481,19 @@ const SelectInput = React.forwardRef(function SelectInput(props, ref) {
     }
   };
 
+  // Support autofill.
+  const handleChange = (event) => {
+    const child = childrenArray.find((childItem) =>
+      areEqualValues(event.target.value, childItem.props.value),
+    );
+
+    if (child === undefined) {
+      return;
+    }
+
+    handleValueChange(event, child, multiple ? [child.props.value] : child.props.value);
+  };
+
   const handleItemClick = (child) => (event) => {
     didPointerDownOnItemRef.current = false;
 
@@ -508,7 +506,7 @@ const SelectInput = React.forwardRef(function SelectInput(props, ref) {
 
     if (multiple) {
       newValue = Array.isArray(value) ? value.slice() : [];
-      const itemIndex = value.indexOf(child.props.value);
+      const itemIndex = value.findIndex((v) => areEqualValues(v, child.props.value));
       if (itemIndex === -1) {
         newValue.push(child.props.value);
       } else {