diff --git a/docs/guide.md b/docs/guide.md
index 037637bc..73d13bcd 100644
--- a/docs/guide.md
+++ b/docs/guide.md
@@ -191,6 +191,20 @@ Default value is `pyinstrument.renderers.HTMLRenderer`. The supported renderers
 
 You can configure the sampling interval using setting's variable `PYINSTRUMENT_INTERVAL`. Default value is 0.001.
 
+**Use a Content Security Policy nonce**
+
+If your site's Content Security Policy disallows inline scripts, set
+`PYINSTRUMENT_CSP_NONCE` to a callback that returns the nonce for the current
+response. Pyinstrument calls the callback once and adds the returned value to
+every inline script in the profiling page.
+
+```python
+PYINSTRUMENT_CSP_NONCE = get_current_csp_nonce
+```
+
+The same nonce must be allowed by the response's `Content-Security-Policy`
+header. Pyinstrument does not generate the nonce or modify the policy header.
+
 ## Profile a web request in Flask
 
 A simple setup to profile a Flask application is the following:
diff --git a/pyinstrument/middleware.py b/pyinstrument/middleware.py
index f85bee40..b2d90f5f 100644
--- a/pyinstrument/middleware.py
+++ b/pyinstrument/middleware.py
@@ -34,6 +34,20 @@ def get_renderer(path) -> Renderer:
         return HTMLRenderer()
 
 
+def get_csp_nonce():
+    """Return the configured CSP nonce, if any."""
+    nonce_callback = getattr(settings, "PYINSTRUMENT_CSP_NONCE", None)
+    if nonce_callback is None:
+        return None
+    if not callable(nonce_callback):
+        raise ValueError("PYINSTRUMENT_CSP_NONCE should be a callable")
+
+    nonce = nonce_callback()
+    if not isinstance(nonce, str):
+        raise ValueError("PYINSTRUMENT_CSP_NONCE callback return value should be a string")
+    return nonce
+
+
 class ProfilerMiddleware(MiddlewareMixin):  # type: ignore
     def process_request(self, request):
         profile_dir = getattr(settings, "PYINSTRUMENT_PROFILE_DIR", None)
@@ -62,6 +76,8 @@ def process_response(self, request, response):
 
             configured_renderer = getattr(settings, "PYINSTRUMENT_PROFILE_DIR_RENDERER", None)
             renderer = get_renderer(configured_renderer)
+            if isinstance(renderer, HTMLRenderer):
+                renderer.csp_nonce = get_csp_nonce()
 
             output = renderer.render(profile_session)
 
@@ -107,6 +123,7 @@ def process_response(self, request, response):
                     return HttpResponse(output)  # type: ignore
                 else:
                     renderer = HTMLRenderer()
+                    renderer.csp_nonce = get_csp_nonce()
                     output = renderer.render(profile_session)
                     return HttpResponse(output)  # type: ignore
             else:
diff --git a/pyinstrument/renderers/html.py b/pyinstrument/renderers/html.py
index e8926771..ca2afc33 100644
--- a/pyinstrument/renderers/html.py
+++ b/pyinstrument/renderers/html.py
@@ -1,6 +1,7 @@
 from __future__ import annotations
 
 import codecs
+import html
 import json
 import sys
 import tempfile
@@ -37,6 +38,11 @@ class HTMLRenderer(Renderer):
     Options to pass to the preprocessors, like :attr:`FrameRenderer.processor_options`.
     """
 
+    csp_nonce: str | None
+    """
+    A nonce to add to inline script elements in the rendered HTML.
+    """
+
     def __init__(
         self,
         *,
@@ -62,6 +68,7 @@ def __init__(
             )
 
         self.resample_interval = resample_interval
+        self.csp_nonce = None
 
         # These settings are passed down to JSONForHTMLRenderer, and can be
         # used to modify its output. E.g. they can be used to lower the size
@@ -106,6 +113,11 @@ def render(self, session: Session):
 
         js = js_file.read_text(encoding="utf-8")
         css = css_file.read_text(encoding="utf-8")
+        nonce_attribute = (
+            f' nonce="{html.escape(self.csp_nonce, quote=True)}"'
+            if self.csp_nonce is not None
+            else ""
+        )
 
         page = f"""<!DOCTYPE html>
             <html>
@@ -115,10 +127,10 @@ def render(self, session: Session):
             <body>
                 <div id="app"></div>
 
-                <script>{js}</script>
+                <script{nonce_attribute}>{js}</script>
                 <style>{css}</style>
 
-                <script>
+                <script{nonce_attribute}>
                     const sessionData = {session_json};
                     pyinstrumentHTMLRenderer.render(document.getElementById('app'), sessionData);
                 </script>
diff --git a/test/test_django_middleware.py b/test/test_django_middleware.py
index 3f02850f..acff8b1e 100644
--- a/test/test_django_middleware.py
+++ b/test/test_django_middleware.py
@@ -3,6 +3,7 @@
 django = pytest.importorskip("django")
 
 from django.conf import settings  # noqa: E402
+from django.http import HttpResponse  # noqa: E402
 from django.test import RequestFactory  # noqa: E402
 
 
@@ -52,3 +53,28 @@ def test_profile_dir_still_profiles_when_callback_allows(tmp_path):
             assert hasattr(request, "profiler")
         finally:
             stop_profiler(request)
+
+
+def test_csp_nonce_is_applied_to_profile_scripts():
+    from django.test import override_settings
+
+    nonce_calls = 0
+
+    def get_nonce():
+        nonlocal nonce_calls
+        nonce_calls += 1
+        return 'nonce&"value'
+
+    with override_settings(PYINSTRUMENT_CSP_NONCE=get_nonce):
+        request = RequestFactory().get("/?profile")
+        middleware = make_middleware()
+        try:
+            middleware.process_request(request)
+            response = middleware.process_response(request, HttpResponse())
+        except Exception:
+            stop_profiler(request)
+            raise
+
+    output = response.content.decode()
+    assert nonce_calls == 1
+    assert output.count('<script nonce="nonce&amp;&quot;value">') == 2