diff --git a/source/core/index.ts b/source/core/index.ts
index a6fc9ff33..20a3e2f4d 100644
--- a/source/core/index.ts
+++ b/source/core/index.ts
@@ -1,5 +1,5 @@
 import {promisify} from 'util';
-import {Duplex, Readable} from 'stream';
+import {Duplex, Writable, Readable} from 'stream';
 import {ReadStream} from 'fs';
 import {URL, URLSearchParams} from 'url';
 import {Socket} from 'net';
@@ -56,6 +56,8 @@ const kOriginalResponse = Symbol('originalResponse');
 const kRetryTimeout = Symbol('retryTimeout');
 export const kIsNormalizedAlready = Symbol('isNormalizedAlready');
 
+const destroyedWithoutErrorCodes = new Set(['ECANCELED', 'ERR_STREAM_DESTROYED']);
+
 const supportsBrotli = is.string((process.versions as any).brotli);
 
 export interface Agents {
@@ -1400,6 +1402,25 @@ export default class Request extends Duplex implements RequestEvents<Request> {
 		// TODO: Remove this when targeting Node.js >= 12
 		this._progressCallbacks = [];
 
+		const unlockWrite = (): void => this._unlockWrite();
+		const lockWrite = (): void => this._lockWrite();
+
+		this.on('pipe', (source: Writable) => {
+			source.prependListener('data', unlockWrite);
+			source.on('data', lockWrite);
+
+			source.prependListener('end', unlockWrite);
+			source.on('end', lockWrite);
+		});
+
+		this.on('unpipe', (source: Writable) => {
+			source.off('data', unlockWrite);
+			source.off('data', lockWrite);
+
+			source.off('end', unlockWrite);
+			source.off('end', lockWrite);
+		});
+
 		this.on('pipe', source => {
 			if (source instanceof IncomingMessage) {
 				this.options.headers = {
@@ -1409,6 +1430,11 @@ export default class Request extends Duplex implements RequestEvents<Request> {
 			}
 		});
 
+		const {json, body, form} = options;
+		if (json || body || form) {
+			this._lockWrite();
+		}
+
 		if (kIsNormalizedAlready in options) {
 			this.options = options as NormalizedOptions;
 		} else {
@@ -1861,6 +1887,30 @@ export default class Request extends Duplex implements RequestEvents<Request> {
 		return normalizePromiseArguments(options as NormalizedOptions, defaults);
 	}
 
+	_lockWrite(): void {
+		const onLockedWrite = (): never => {
+			throw new TypeError('The payload has been already provided');
+		};
+
+		// `stream.pipeline()` ends the destination from its own `end` listener, after the lock is back in place (Node.js 17.3+). Ending without a payload writes nothing, so it stays allowed.
+		const endWithoutPayload = (...args: unknown[]): this => {
+			const [chunk] = args;
+			if (chunk !== undefined && chunk !== null && typeof chunk !== 'function') {
+				onLockedWrite();
+			}
+
+			return Duplex.prototype.end.apply(this, args as Parameters<Duplex['end']>) as this;
+		};
+
+		this.write = onLockedWrite;
+		this.end = endWithoutPayload;
+	}
+
+	_unlockWrite(): void {
+		this.write = super.write;
+		this.end = super.end;
+	}
+
 	async _finalizeBody(): Promise<void> {
 		const {options} = this;
 		const {headers} = options;
@@ -1938,6 +1988,10 @@ export default class Request extends Duplex implements RequestEvents<Request> {
 					}
 				}
 			}
+		} else if (cannotHaveBody) {
+			this._lockWrite();
+		} else {
+			this._unlockWrite();
 		}
 
 		this[kBodySize] = Number(headers['content-length']) || undefined;
@@ -2205,11 +2259,19 @@ export default class Request extends Duplex implements RequestEvents<Request> {
 			body.once('error', (error: NodeJS.ErrnoException) => {
 				this._beforeError(new UploadError(error, this));
 			});
-		} else if (!is.undefined(body)) {
-			this._writeRequest(body, undefined, () => {});
-			currentRequest.end();
-		} else if (this._cannotHaveBody || this._noPipe) {
-			currentRequest.end();
+		} else {
+			this._unlockWrite();
+
+			if (!is.undefined(body)) {
+				this._writeRequest(body, undefined, () => {});
+				currentRequest.end();
+
+				this._lockWrite();
+			} else if (this._cannotHaveBody || this._noPipe) {
+				currentRequest.end();
+
+				this._lockWrite();
+			}
 		}
 
 		this.emit('request', request);
@@ -2441,7 +2503,9 @@ export default class Request extends Duplex implements RequestEvents<Request> {
 					void this._onResponse(requestOrResponse as IncomingMessageWithTimings);
 				});
 
+				this._unlockWrite();
 				this.end();
+				this._lockWrite();
 			} else {
 				void this._onResponse(requestOrResponse as IncomingMessageWithTimings);
 			}
@@ -2646,9 +2710,19 @@ export default class Request extends Duplex implements RequestEvents<Request> {
 				return;
 			}
 
-			this[kRequest]!.end((error?: Error | null) => {
+			const request = this[kRequest]!;
+
+			request.end((error?: NodeJS.ErrnoException | null) => {
 				if (error) {
 					// `ClientRequest.end()` can report the same failure as the request's `error` event. Route it through Got's retry handling without completing `_final`, so this Duplex does not finish a failed upload.
+					// A request destroyed without an error reports `ECANCELED` here before its `error` event carries the retryable cause, and `close` always follows that event.
+					if (destroyedWithoutErrorCodes.has(error.code!) && !(request as ClientRequest & {closed?: boolean}).closed) {
+						request.once('close', () => {
+							this._beforeError(error);
+						});
+						return;
+					}
+
 					this._beforeError(error);
 					return;
 				}
diff --git a/test/retry.ts b/test/retry.ts
index 885a9765d..db0a9dbb2 100644
--- a/test/retry.ts
+++ b/test/retry.ts
@@ -48,6 +48,44 @@ const createRequestWithEndError = (scenario: RequestEndErrorScenario): http.Clie
 	return request;
 };
 
+const createDestroyedRequest = ({emitsError, closed = false}: {emitsError: boolean; closed?: boolean}): http.ClientRequest => {
+	const request = new EventEmitter() as http.ClientRequest & {closed: boolean};
+	request.closed = closed;
+
+	// @ts-expect-error Mocking the behaviour of a ClientRequest
+	request.write = (_chunk: unknown, _encoding: unknown, callback?: () => void) => {
+		process.nextTick(() => callback?.());
+		return true;
+	};
+
+	// @ts-expect-error Mocking the behaviour of a ClientRequest
+	request.end = (callback: (error: Error) => void) => {
+		process.nextTick(() => {
+			callback(Object.assign(new Error('write ECANCELED'), {code: 'ECANCELED'}));
+
+			if (closed) {
+				return;
+			}
+
+			if (emitsError) {
+				request.emit('error', Object.assign(new Error('socket hang up'), {code: 'ECONNRESET'}));
+			}
+
+			request.closed = true;
+			request.emit('close');
+		});
+	};
+
+	request.abort = () => {};
+
+	request.destroy = () => {
+		request.destroyed = true;
+		return request;
+	};
+
+	return request;
+};
+
 const retryImmediately = {
 	calculateDelay: ({computedValue}: {computedValue: number}) => computedValue === 0 ? 0 : 1
 };
@@ -382,6 +420,116 @@ test('retries a refused connection and rejects with the connection error', async
 	t.is(error.request?.retryCount, 2);
 });
 
+test('retries the request error that follows an `ECANCELED` end callback', async t => {
+	let attemptCount = 0;
+	const retries: Array<string | undefined> = [];
+
+	const error = await t.throwsAsync<RequestError>(got.put('http://localhost', {
+		body: 'wow',
+		request: () => {
+			attemptCount++;
+			return createDestroyedRequest({emitsError: true});
+		},
+		retry: {
+			limit: 2,
+			...retryImmediately
+		},
+		hooks: {
+			beforeRetry: [
+				(_options, error) => {
+					retries.push(error?.code);
+				}
+			]
+		}
+	}), {
+		instanceOf: RequestError
+	});
+
+	t.is(error.code, 'ECONNRESET');
+	t.is(attemptCount, 3);
+	t.deepEqual(retries, ['ECONNRESET', 'ECONNRESET']);
+});
+
+test('rejects with `ECANCELED` when the destroyed request emits no error', async t => {
+	let attemptCount = 0;
+
+	const error = await t.throwsAsync<RequestError>(got.put('http://localhost', {
+		body: 'wow',
+		request: () => {
+			attemptCount++;
+			return createDestroyedRequest({emitsError: false});
+		},
+		retry: {
+			limit: 2,
+			...retryImmediately
+		}
+	}), {
+		instanceOf: RequestError
+	});
+
+	t.is(error.code, 'ECANCELED');
+	t.is(attemptCount, 1);
+});
+
+test('rejects with `ECANCELED` when the request already closed', async t => {
+	const error = await t.throwsAsync<RequestError>(got.put('http://localhost', {
+		body: 'wow',
+		request: () => createDestroyedRequest({emitsError: false, closed: true}),
+		retry: 0
+	}), {
+		instanceOf: RequestError
+	});
+
+	t.is(error.code, 'ECANCELED');
+});
+
+test('retries an upload whose socket is destroyed without an error', async t => {
+	const server = http.createServer(request => {
+		request.pause();
+	});
+
+	await new Promise<void>(resolve => {
+		server.listen(0, '127.0.0.1', resolve);
+	});
+
+	t.teardown(() => {
+		server.close();
+	});
+
+	const {port} = server.address() as {port: number};
+	const retries: Array<string | undefined> = [];
+
+	const error = await t.throwsAsync<RequestError>(got.put(`http://127.0.0.1:${port}`, {
+		body: Buffer.alloc(64 * 1024 * 1024),
+		agent: {http: new http.Agent({keepAlive: false})},
+		request: (url, options, callback) => {
+			const request = http.request(url, options, callback);
+			request.once('socket', socket => {
+				setTimeout(() => {
+					socket.destroy();
+				}, 100);
+			});
+			return request;
+		},
+		retry: {
+			limit: 1,
+			...retryImmediately
+		},
+		hooks: {
+			beforeRetry: [
+				(_options, error) => {
+					retries.push(error?.code);
+				}
+			]
+		}
+	}), {
+		instanceOf: RequestError
+	});
+
+	t.is(error.code, 'ECONNRESET');
+	t.deepEqual(retries, ['ECONNRESET']);
+});
+
 test('respects 413 Retry-After', withServer, async (t, server, got) => {
 	let lastTried413access = Date.now();
 	server.get('/', (_request, response) => {
diff --git a/test/stream.ts b/test/stream.ts
index e2069423c..fa198f5e9 100644
--- a/test/stream.ts
+++ b/test/stream.ts
@@ -2,6 +2,8 @@ import {promisify} from 'util';
 import fs = require('fs');
 import {PassThrough as PassThroughStream} from 'stream';
 import stream = require('stream');
+import http = require('http');
+import {AddressInfo} from 'net';
 import test from 'ava';
 import {Handler} from 'express';
 import toReadableStream = require('to-readable-stream');
@@ -69,6 +71,88 @@ test('returns writeable stream', withServer, async (t, server, got) => {
 	t.is(await promise, 'wow');
 });
 
+test('throws on write if body is specified', withServer, (t, server, got) => {
+	server.post('/', postHandler);
+
+	const streams = [
+		got.stream.post({body: 'wow'}),
+		got.stream.post({json: {}}),
+		got.stream.post({form: {}})
+	];
+
+	for (const stream of streams) {
+		t.throws(() => {
+			stream.end('wow');
+		}, {
+			message: 'The payload has been already provided'
+		});
+
+		stream.destroy();
+	}
+});
+
+test('throws on write if no payload method is present', withServer, (t, server, got) => {
+	server.post('/', postHandler);
+
+	const stream = got.stream.get('');
+
+	t.throws(() => {
+		stream.end('wow');
+	}, {
+		message: 'The payload has been already provided'
+	});
+
+	stream.destroy();
+});
+
+test('data written after the body is never sent', async t => {
+	const requests: string[] = [];
+	const server = http.createServer((request, response) => {
+		let body = '';
+		request.setEncoding('utf8');
+		request.on('data', (chunk: string) => {
+			body += chunk;
+		});
+		request.on('end', () => {
+			requests.push(`${request.method!} ${request.url!} ${body}`);
+			response.end('ok');
+		});
+	});
+
+	await new Promise<void>(resolve => {
+		server.listen(0, '127.0.0.1', resolve);
+	});
+	t.teardown(() => {
+		server.close();
+	});
+
+	const {port} = server.address() as AddressInfo;
+	const stream = got.stream.post(`http://127.0.0.1:${port}/upload`, {body: 'abc'});
+
+	t.throws(() => {
+		stream.write('GET /injected HTTP/1.1\r\nHost: localhost\r\n\r\n');
+	}, {
+		message: 'The payload has been already provided'
+	});
+
+	t.is(await getStream(stream), 'ok');
+	t.deepEqual(requests, ['POST /upload abc']);
+});
+
+test('ending a stream without a payload does not throw', withServer, async (t, server, got) => {
+	server.get('/', (_request, response) => {
+		response.end('ok');
+	});
+
+	const stream = got.stream('');
+
+	t.notThrows(() => {
+		stream.end();
+	});
+
+	t.is(await getStream(stream), 'ok');
+});
+
 test('does not throw if using stream and passing a json option', withServer, async (t, server, got) => {
 	server.post('/', postHandler);